abstract：:Recently, it has been suggested that erythropoietin may be useful in the treatment of cardiovascular disease, particularly heart failure. This may be by improving microvascular blood supply and ventricular function through prevention of apoptosis and angiogenesis. Promising results were seen in animals but the few, li...

journal_title：Heart failure reviews

authors： Tilling L,Clapp B

更新日期：2012-05-01 00:00:00

abstract：:The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients...

journal_title：Heart failure reviews

authors： Willemsen S,Hartog JW,Heiner-Fokkema MR,van Veldhuisen DJ,Voors AA

更新日期：2012-03-01 00:00:00

abstract：:In the United States and Europe, approximately 90% of heart failure hospitalizations are due to symptoms and signs of sodium and fluid excess. Congestion is associated with heart failure progression. Venous congestion, rather than a reduced cardiac output, may be the primary hemodynamic factor driving worsening renal ...

journal_title：Heart failure reviews

authors： Costanzo MR,Jessup M

更新日期：2012-03-01 00:00:00

abstract：:In this paper, two different aspects of the relationship between chronic kidney disease and sudden cardiac death (SCD) have been reviewed. In end-stage renal disease patients, SCD risk is increased, and among patients implanted with a cardioverter defibrillator (ICD), dialysed ones carry a superior relative risk compa...

journal_title：Heart failure reviews

authors： Padeletti L,Innocenti L,Paoletti Perini A,Gronda E

更新日期：2011-11-01 00:00:00

abstract：:Anemia is common in Congestive Heart Failure (CHF) and is associated with an increased mortality, morbidity and progressive renal failure. The most common causes of the anemia in CHF are (1) the associated Chronic Kidney Disease (CKD), which causes depression of erythropoietin (EPO) production in the kidney, and (2) e...

journal_title：Heart failure reviews

authors： Silverberg DS

更新日期：2011-11-01 00:00:00

abstract：:In the past decade, cardiac pacing devices (either permanent pacemakers or Implanted Cardioverter Defibrillators) have become increasingly common in patients with heart failure. The manner in which the device is programmed to pace the heart can have significant implications on cardiac hemodynamics, both positive and n...

journal_title：Heart failure reviews

authors： Lahiri MK,Mao JT,Schuger CD

更新日期：2011-09-01 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) has revolutionized the treatment of selected patients with systolic heart failure. It is well recognized, however, that the symptomatic response to and the outcome of CRT is highly variable. The degree of pre-implant mechanical dyssynchrony and the extent as well as the localiza...

journal_title：Heart failure reviews

authors： Leyva F,Foley PW

更新日期：2011-05-01 00:00:00

abstract：:Sympathetic-parasympathetic interaction plays a major role in the evolution and outcome of many cardiovascular disorders. Nonetheless, a thorough understanding of this relationship and of its potential implications for prognosis and management still escapes many cardiologists. This article reviews the background of sy...

journal_title：Heart failure reviews

authors： Schwartz PJ,De Ferrari GM

更新日期：2011-03-01 00:00:00

abstract：:Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. In this regard, STAT3 i...

journal_title：Heart failure reviews

authors： Haghikia A,Stapel B,Hoch M,Hilfiker-Kleiner D

更新日期：2011-01-01 00:00:00

abstract：:Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...

journal_title：Heart failure reviews

authors： Glass CE,Singal PK,Singla DK

更新日期：2010-11-01 00:00:00

abstract：:Heart failure (HF) is characterized by the elaboration of a portfolio of pro-inflammatory cytokines and inflammatory mediators that are considered to contribute to disease progression by virtue of the deleterious effects that these molecules exert on the heart and circulation. Recent studies have suggested that these ...

journal_title：Heart failure reviews

authors： Bozkurt B,Mann DL,Deswal A

更新日期：2010-07-01 00:00:00

abstract：:The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are freq...

journal_title：Heart failure reviews

authors： Rocchiccioli JP,McMurray JJ,Dominiczak AF

更新日期：2010-07-01 00:00:00

abstract：:Dramatic advances in molecular biology dominated twentieth century biomedical science and delineated the function of individual genes and molecules in exquisite detail. However, biological processes cannot be fully understood based on the properties of individual genes and molecules alone, since these elements act in ...

journal_title：Heart failure reviews

authors： Adams KF

更新日期：2010-07-01 00:00:00

abstract：:This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect on the binding of T3 to thyroid ho...

journal_title：Heart failure reviews

authors： Wiersinga WM

更新日期：2010-03-01 00:00:00

abstract：:Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...

journal_title：Heart failure reviews

authors： Dhesi P,Tehrani F,Fuess J,Schwarz ER

更新日期：2010-01-01 00:00:00

abstract：:Acute heart failure syndromes (AHFS) are associated with the rapid onset of heart failure (HF) signs and symptoms. Hospitalizations for AHFS continue to rise and are associated with significant mortality and morbidity. Several pharmacological agents are currently approved for the treatment of AHFS, but their use is as...

journal_title：Heart failure reviews

authors： Khan H,Metra M,Blair JE,Vogel M,Harinstein ME,Filippatos GS,Sabbah HN,Porchet H,Valentini G,Gheorghiade M

更新日期：2009-12-01 00:00:00

abstract：:The sympathetic nervous system provides the most powerful stimulation of cardiac function, brought about via norepinephrine and epinephrine and their postsynaptic beta-adrenergic receptors. More than 30 years after the first use of practolol in patients with heart failure beta blockers are now the mainstay of the phar...

journal_title：Heart failure reviews

authors： El-Armouche A,Eschenhagen T

更新日期：2009-12-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia...

journal_title：Heart failure reviews

authors： Khayat R,Patt B,Hayes D Jr

更新日期：2009-09-01 00:00:00

abstract：:Objective and validated measures of depression/distress (anxiety and anger) are available and readily usable at the bedside or in clinic. Foremost among these is the Patient's Health Questionnaire--an adaptation of DSM IV criteria for Major Depressive Disorder that permits administration and scoring by nursing or phys...

journal_title：Heart failure reviews

authors： Ketterer MW,Knysz W

更新日期：2009-03-01 00:00:00

abstract：:Patients diagnosed with CHF have disproportionately high rates of depression. Research has demonstrated significant consequences of depression in patients with CHF including poor quality of life, worse medical adherence and increased health complications, health care utilization, and medical costs. Despite these conse...

journal_title：Heart failure reviews

authors： O'Hea E,Houseman J,Bedek K,Sposato R

更新日期：2009-03-01 00:00:00

abstract：:Healing after myocardial infarction (MI) is a well-orchestrated time-dependent process that involves inflammation, tissue repair with extracellular collagen matrix (ECCM) deposition and scar formation, and remodeling of myocardial structure, matrix, vasculature, and function. Rapid early ECCM degradation followed by s...

journal_title：Heart failure reviews

authors： Jugdutt BI

更新日期：2008-12-01 00:00:00

abstract：:Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, i...

journal_title：Heart failure reviews

authors： Danziger RS

更新日期：2008-09-01 00:00:00

abstract：:There is little doubt that the discovery of ischemic preconditioning (PC) has been one of the fundamental milestones in the field of ischemic biology in the past 20 years. The purpose of this article is to review the pathophysiology and molecular basis of the late phase of myocardial PC. The exploitation of late PC fo...

journal_title：Heart failure reviews

authors： Bolli R,Li QH,Tang XL,Guo Y,Xuan YT,Rokosh G,Dawn B

更新日期：2007-12-01 00:00:00

abstract：:Brief ischemia to the myocardium initiates a cascade of biochemical events in cardiac myocytes that protects the heart muscle during subsequent ischemic insults. This phenomenon is called ischemic preconditioning. If an acute myocardial infarction is preceded by preinfarction angina, it results in smaller infarction s...

journal_title：Heart failure reviews

authors： Rezkalla SH,Kloner RA

更新日期：2007-12-01 00:00:00

abstract：:Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...

journal_title：Heart failure reviews

authors： Parissis JT,Farmakis D,Nieminen M

更新日期：2007-06-01 00:00:00

abstract：:Cardiac hypertrophy is promoted by adrenergic over-activation and represents an independent risk factor for cardiovascular morbidity and mortality. The basic knowledge about mechanisms by which sustained adrenergic activation promotes myocardial growth, as well as understanding how structural changes in hypertrophied ...

journal_title：Heart failure reviews

authors： Osadchii OE

更新日期：2007-03-01 00:00:00

abstract：:B-Type natriuretic peptide (BNP) is elevated in states of increased ventricular wall stress. BNP is most commonly used to rule out congestive heart failure (CHF) in dyspneic patients. BNP levels are influenced by age, gender and, to a surprisingly large extent, by body mass index (BMI). In addition, it can be elevated...

journal_title：Heart failure reviews

authors： Burke MA,Cotts WG

更新日期：2007-03-01 00:00:00

abstract：:Heart failure (HF) is associated with a high morbidity and mortality in the Western World. Our knowledge of the epidemiology, pathophysiology, and therapy has improved dramatically during the last 20 years. Pharmacological treatment, as it stands today, is a combination of preventive and symptomatic strategies. The ma...

journal_title：Heart failure reviews

authors： Adorisio R,De Luca L,Rossi J,Gheorghiade M

更新日期：2006-06-01 00:00:00

abstract：:Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, p...

journal_title：Heart failure reviews

authors： Allard ML,Jeejeebhoy KN,Sole MJ

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Transient left ventricular apical ballooning syndrome also called Tako-Tsubo cardiomyopathy is defined as a syndrome consisting of stress induced apical ballooning of the left ventricle and normal coronary arteries. The majority of the published reports are case reports or case series with a small number of ...

journal_title：Heart failure reviews

authors： Donohue D,Movahed MR

更新日期：2005-12-01 00:00:00

abstract：:This collection of papers covers developments in a rapidly growing area, sarcomeric proteins in hypertrophied and failing myocardium. Advances in our understanding of the biochemistry and biophysics of crossbridge cycling, contributions of thick versus thin filament and the emerging role of titin, the importance and m...

journal_title：Heart failure reviews

authors： LeWinter MM,VanBuren P

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Whether mechanical restraint of the left ventricle (LV) can influence remodeling following myocardial infarction (MI) remains poorly understood. The following discussion details three studies examining the effects of surgically placing a cardiac support device (CSD) over the entire epicardial surface, on inf...

journal_title：Heart failure reviews

authors： Blom AS,Pilla JJ,Gorman RC 3rd,Gorman JH,Mukherjee R,Spinale FG,Acker MA

更新日期：2005-06-01 00:00:00

abstract：:Genomic mechanisms of mineralocorticoid action have been increasingly elucidated over the past four decades. In renal epithelia, the main effect is an increase in sodium transport through activation and de novo synthesis of epithelial sodium channels. This leads to increased concentrations of intracellular sodium acti...

journal_title：Heart failure reviews

authors： Wehling M

更新日期：2005-01-01 00:00:00

abstract：:Congestive heart failure is most often caused by scar from coronary occlusion. The transition from occluded vessel to scar to dilation results in a remodeled ventricle that changes shape from ellipse to sphere. This shape change following an index event is called remodeling and a surgical approach for restoration (bri...

journal_title：Heart failure reviews

authors： Buckberg GD

更新日期：2004-10-01 00:00:00

abstract：:Beta-blockers are not an homogeneous group of agents. Only three beta-blockers, carvedilol, bisoprolol and metoprolol succinate, have had favorable effects on prognosis in controlled clinical trials in the patients with chronic heart failure. However, pharmacological differences exist between them. Metoprolol and biso...

journal_title：Heart failure reviews

authors： Metra M,Cas LD,di Lenarda A,Poole-Wilson P

更新日期：2004-04-01 00:00:00

abstract：:The discovery of cardiac natriuretic peptides two decades ago has lead to considerable research to investigate their biochemical and physiological properties. Clearly the heart is not just a pump but is also an endocrine organ that together with the kidneys control volume overload. The natriuretic peptides are a group...

journal_title：Heart failure reviews

authors： Azzazy HM,Christenson RH

更新日期：2003-10-01 00:00:00

abstract：:The evolving paradigm of heart failure has now been expanded to include the favorable neurohormonal, structural and hemodynamic profile of B-type natriuretic peptide [BNP]. As a marker of left ventricular dysfunction, BNP is a practical tool that facilitates diagnosis, contributes to prognostic evaluations and tracks ...

journal_title：Heart failure reviews

authors： Yancy CW

更新日期：2003-10-01 00:00:00

abstract：:Cell transplantation is emerging as a new treatment designed tot improve the poor outcome of patients with cardiac failure. Its rationale is that implantation of contractile cells into postinfarction scars can functionally rejuvenate these areas. Primarily for practical reasons, autologous skeletal myoblasts have been...

journal_title：Heart failure reviews

authors： Menasché P

更新日期：2003-07-01 00:00:00

abstract：:The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by induci...

journal_title：Heart failure reviews

authors： Calderone A

更新日期：2003-01-01 00:00:00

abstract：:Nitric oxide degradation linked to endothelial dysfunction plays a central role in cardiovascular diseases. Superoxide producing enzymes such as NADPH oxidase and xanthine oxidase are responsible for NO degradation as they generate a variety of reactive oxygen species (ROS). Moreover, superoxide is rapidly degraded by...

journal_title：Heart failure reviews

authors： de Gasparo M

更新日期：2002-10-01 00:00:00